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NaturextTM Immune+ AC Essence is made from Antrodia Camphorata Mycelia, a Rare Fungus found naturally only in Taiwan and have been used by the Chinese as a Cancer Preventive Health Supplement for more than 50 years.
Antrodia Camphorata is rich in Flavonoids, Terpenoids, Polyphenolics and Polysaccharides. The known main Bioactive Compounds found in AC are: Polysaccharides, Superoxide Dismutase (SOD), and Triterpenes.
Triterpenes, the most important Bioactive Ingredient found in AC, is a compound which exhibits Anti-Cancer, Anti-Virus, Anti-Oxidant, Hepatoprotection and Cholesterol Inhibition Properties.
Antrodia Camphorata (AC) has been proven to be more potent than Ganoderma Lucidium (Lingzhi) in pharmacological activities. Compared to the well known Ganoderma Licudium (Lingzhi) where less than 50 types of Triterpenes are found, AC contains more than 200 types of Triterpenes. In addition, the concentration of Triterpenes found in AC is 10-15 times higher than Ganoderma Lucidium.
Naturext Immune+ AC EssenceTM also uses a patented solid state fermentation process to cultivate Antrodia Camphorata to ensure highest quality and consistency in its manufacturing process. In vitro experiments have shown that the cultivated Naturext Immune+ AC EssenceTM with active anti cancer compound Antroquinonol demonstrated suprior anti cancer cell viability performance against wild Antrodia Camphorata.
APPLICATIONS:
Anti-allergenic, strengthen immune function
Anti-cancer, chemoprevention
Anti-fatigue, anti-oxidation, anti-LDL cholesterol synthesis
Anti-viral Hepatitis, Anti-hepatoxication, Hepatoprotection
Autoimmune diseases
Chronic Hepatitis B - Detail Complimentary & Adjuvant Application Chart:
| Disclaimer: This information is intended for physician information purposes only and is not intended as a substitute for advise from a physician or other health care professional and should not be used for the diagnosis or treatment of any health problem or for prescription of any medication or other treatment. Do not discontinue any other medical treatments without first consulting your doctor. |
References: 1: Planta Med. 2007 Oct;73(13):1412-5. Epub 2007 Oct 11.
"A new cytotoxic agent from solid-state fermented mycelium of Antrodia Camphorata."
New Chemical Entity isolated from Antrodia Camphorata:
Pharmacological Properties and Mechanism of Actions:
Antroquinonol is a MEK1 inhibitor, targeting the Ras/Raf/MEK/ERK pathway, it also decrease the PI3K/Akt/mTOR expression.
AntroquinonolTM could inhibit proferation of liver, lung, breast and prostate cancer cells. AntroquinonolTM
induced S phase arrest of HepG2 cells when they are pretreated with synchronization. After synchronization with Antroquinonol, it decreases all cell cycle regulatory protein and cell growth related protein (including cyclin A, cyclin D, cyclin E, cdk2, cdk4, Rb, p53, Akt and MAPK). Antroquinonol inhibits protein synthesis through translation related protein 4E-BP1 and elF4E.
AntroquinonolTM for the treatment of multiple forms of cancer has been proven in vivo. The compound has passed in-vivo efficacy, ADME/toxicology for at least three kinds of cancer (NSCLC, liver and breast cancer) compared with the chemotherapy drugs Mitomycin and Taxol as positive control. No drug resistance was observed during in-vivo studies. This indicates that the drug can be considered a long-term orally-administered cancer therapy.
| Antroquinonol MTT ASSAY*: | IC 50 (ug/ml) |
Colon cancer |
0.92 |
Osteosarcoma (Bone) MG-63 |
2.09 |
Pancreatic BxPC-3 |
1.44 |
Oral Squamous Cell Carcinoma SCC-25 |
1.05 |
Bladder Cancer TSGH 8301 |
1.05 |
Gastric Cancer TSGH 9201 |
1.32 |
Lymphoma U937 |
9.71 |
Squamous Carcinoma (Skin) A431 |
0.18 |
Serous Cystaden Carcinoma (Ovarian) ES-2 |
0.80 |
Hormone Sensitive Hepatoma Hep 3B |
0.05 |
Non-hormone Sensitive Hepatoma HepG2 |
1.68 |
Non Small Cell Lung Cancer A459 |
0.45 |
Hormone sensitive Prostate Cancer LNCaP |
2.38 |
Primitive neuroectodermal tumor SK-N-MC P10 |
0.05 |
Non-hormone sensitive Prostate Cancer DU145 |
1.81 |
Hormone Sensitive Breast Cancer MCF-7 |
0.85 |
Non-hormone Sensitive Breast Cancer MDA-MB-231 |
1.03 |
Such symptoms include diarrhea and non-systemic toxic reactions. Compared to other anti-cancer drugs on the market, Antroquinonol® is the only such natural compound that does not elicit side effects.
PD/PK studies have shown that Antroquinonol® bioactivity begins immediately upon being absorbed through the mucosa, allowing for convenient oral administration. Furthermore, studies have shown that the drug does not remain in the body after a period of 13-15 hours.
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